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Comparing patients who received lenalidomide enzalutamide plus dexamethasone as second-line versus later repair therapy, the ORR appeared greater with early treatment. An increased percentage of patients receiving second-line therapy had previously had SCT, although more patients receiving later repair therapy had previously received bortezomib and thalidomide. In more subanalyses of MM 009 and MM 010, Foa and colleagues reported that among 154 patients with IgA illness at baseline, lenalidomide plus dexamethasone was associated with a somewhat greater ORR than dexamethasone alone. The CR rate in patients with IgA infection have been treated with lenalidomide plus dexamethasone, versus dexamethasone alone, was 18. Hands down the and 03-dec, respectively.

Likewise, in patients without IgA infection at baseline, lenalidomide plus dexamethasone reached a higher ORR in contrast to dexamethasone alone. A different analysis demonstrated the superiority of lenalidomide plus dexamethasone in contrast to dexamethasone alone Organism was independent of standard ECOG performance status. In this analysis, patients with an ECOG scores of 0 or 1 had significantly greater ORR with lenalidomide plus dexamethasone compared with dexamethasone alone. Also, age didn't determine response to lenalidomide, with another subanalysis showing that ORR was somewhat higher for lenalidomide plus dexamethasone compared with dexamethasone alone for patients aged 65 years, years, and 75 years. In a subgroup analysis of 682 patients with serum creatinine degrees of 2.

5 mg/dL at standard, lenalidomide BMN 673 plus dexamethasone notably improved reaction charge compared with dexamethasone alone in patients with normal renal function and in those with mild and moderate renal impairment. The ORR wasn't dramatically different between lenalidomide plus dexamethasone and dexamethasone alone in the 28 patients with significant renal impairment, with CR rates carrying out a similar trend to ORR. Eventually, a post hoc analysis of data from the MM 009 and MM 010 trials indicated that dexamethasone dose reductions improved the efficacy of lenalidomide plus dexamethasone treatment compared with patients who continued to receive dexamethasone at the planned dose. Patients assigned to lenalidomide plus dexamethasone and who had a following dexamethasone serving reduction experienced a notably greater ORR and CR rate compared with patients who continued to receive the standard dexamethasone program in combination with lenalidomide.

Within an continuing Dutch sympathetic need plan, patients with relapsed or refractory MM were handled with lenalidomide 25 mg/day on days 21 every 28 days, in combination with dexamethasone 40 mg/day on days 18 until disease progression, unacceptable toxicity, or for a maximum of eight classes. Fifteen patients received lenalidomide 10 mg/day maintenance therapy without dexamethasone after 8 courses of therapy.